Heteroatom Analogues of Hydrocodone: Synthesis and Biological Activity

Heteroatom analogues of hydrocodone, in which the N-methyl functionality was replaced with oxygen, sulfur,
sulfoxide, and sulfone, were prepared by a short sequence from the
ethylene glycol ketal of hydrocodone; a carbocyclic analogue of bisnorhydrocodone
was also prepared. The compounds were tested for receptor binding
and revealed moderate levels of activity for the sulfone analogue
of hydrocodone.