Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis

The goal of this study was to begin to understand the temporal dynamics of inflammation induced dysbiosis of the periodontal microbiota. To accomplish this goal, periodontitis was induced in the rat using ligatures to observe changes in the microbiota and the host without the addition of exogenous pathogens. Global differential gene expression in periodontal tissues was evaluated in health, disease and after treatment with RvE1 to provide an unbiased assessment of inflammatory changes. In parallel, 16S rDNA sequencing was employed in the same experiments to determine the impact of local inflammation on the composition of subgingival bacteria. The data suggest a dynamic, temporal interaction between local inflammation and the composition of the periodontal microbiota.