Mechanochemically Activated Asymmetric Organocatalytic Domino Mannich Reaction-Fluorination
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https://figshare.com/articles/dataset/Mechanochemically_Activated_Asymmetric_Organocatalytic_Domino_Mannich_Reaction-Fluorination/12946891
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资源简介：
Mechanochemical
activation effectively mediated asymmetric organocatalytic
domino Mannich addition followed by diastereoselective fluorination.
The Mannich reactions of pyrazolones and to a lesser extent those
of isoxazolones were effective under solvent-free ball-milling conditions.
This reaction in combination with a chiral squaramide catalyst provided
corresponding products in high yields and enantiomeric purities up
to 99:1 e.r. and as a single diastereomer. DFT calculations revealed
reasons for high diastereoselectivity.
创建时间：
2020-09-11
