Comprehensive transcriptomic profiling of breast cancer patients in SweBCG 91-RT. Comprehensive transcriptomic profiling of breast cancer patients in SweBCG 91-RT

We performed a retrospective analysis of the SweBCG 91-RT trial, which randomized women with node-negative stage I-IIA breast cancer to whole breast radiotherapy or no radiotherapy following breast-conserving surgery with minimal use of adjuvant systemic treatment. Primary tumors were profiled with the GeneChip Human Exon 1.0 ST microarray. Overall design: RNA was isolated from FFPE tissue specimens of the SweBCG 91-RT trial and whole transcriptome profiling was performed. Profiling was successful for 765 patients.