Small RNA sequencing of oxidative low-density lipoprotein treated endothelial cells

Atherosclerosis (AS) is a common cardiovascular disease with high incidence rate and mortality. The injury and dysfunction of endothelial cells are the early markers of AS. Oxidative low-density lipoprotein (Ox-LDL) is a key risk factor for the development of AS. Ox-LDL promotes endothelial cells apoptosis, induces inflammation and oxidative stress of endothelial cells. Small noncoding RNA (sncRNA) mainly include Piwi-interacting RNA (piRNA), small nucleolar RNA (snoRNA), small nuclear RNA (snRNA), microRNA (miRNA) and repeat-associated RNA. We used small RNA sequencing to analyze the effect of ox-LDL on the expression of sncRNAs in endothelial cells, and identify the sncRNA which is related to ox-LDL induced endothelial cells dysfunction.