Crystal structure of TLR8 in complex with its antagonist
收藏Protein Data Bank Japan2026-03-04 更新2026-04-19 收录
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Crystal structure of TLR8 in complex with its antagonist Descriptor: (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Shimizu, T, Sakaniwa, K. Deposit date: 2022-08-16 Release date: 2023-09-27 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus. Eur.J.Pharmacol., 957, 2023
Toll样受体8（TLR8）与其拮抗剂结合的晶体结构，配体详情：(2R,6R)-4-(8-氰基喹啉-5-基)-N-[(3S,4R)-4-氟吡咯烷-3-基]-6-甲基-吗啉-2-甲酰胺、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Shimizu T、Sakaniwa K；存档日期：2022-08-16；发布日期：2023-09-27；最后修改日期：2026-03-04；实验方法：X射线衍射（分辨率2.9埃）；引用文献：《新型Toll样受体7/8特异性拮抗剂E6742可改善狼疮小鼠模型的临床相关疾病参数》，《欧洲药理学杂志》，第957卷，2023年
创建时间：
2022-08-16
