Differential Gene Expression and Pathway Analysis in Juvenile Nasopharyngeal Angiofibroma Using RNA-Sequencing

We have identified a set of differentially expressed genes in the juvenile nasopharyngeal angiofibroma transcriptome and predict activation of the vascular endothelial growth factor and interleukin-6 signaling pathways, which represent potential molecular targets for therapy in patients with inoperable or persistent disease. These results implicate the role of fibroblasts as a tumor cell type driving disease progression. Overall design: mRNA transcriptome profiles of cultured fibroblasts from two juvenile nasopharyngeal angiofibroma tumor explants and two fibroblast replicates cultured from normal adult tonsil tissue