Datasets for Belal et al. 'Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models'

Processed dataset and workflows When unzipped, each figure folder has its own README, all scripts/code, processed data files, SVG panels and statistics for that figure Figure 1: gabazine sensitivity of ChI-evoked PSCs in dSPNs and iSPNs Figure 2: ChI-evoked PSCs compared between dSPNs and iSPNs Figure 3: GABAA delta-subunit CRISPR knockdown and the slow PSC component + NGFI-evoked GABAergic currents in SPNs Figure 7: GRAB-ACh3.0 imaging of ChI-evoked ACh release in MCI-Park and control mice Figure 8: ChI-evoked GABAergic PSCs in MCI-Park and control mice Figure 9: ChI-evoked GABAergic input after 6-OHDA MFB lesion Figure 10: NPY-interneuron-evoked input after 6-OHDA MFB lesion Figure 11: RNAscope and ChI to NGF PSC analysis, including Figure S6 RNAscope data Figure S5: independent 6-OHDA ChI-evoked PSC study Folder layout Most figure folders contain *.R or *.ipynb analysis scripts xlsx/ processed spreadsheets and csv tables svg/ figure panels and fit diagnostics Workflow For electrophysiology figures, the usual workflow is: 1. Download the raw NWB files from DANDI Archive DANDI:001832 2. Run the figure data-processing script to create averaged traces in `xlsx/` 3. Run the figure analysis script to fit traces and create summary spreadsheets `xlsx` and `csv` formats 4. Run the figure graphs script to plot SVG panels and write statistics tables Figure 7 imaging and Figure 11 RNAscope use related workflows described in their figure READMEs Raw data and analysis code availability Raw NWB data are available from the DANDI Archive as `DANDI:001832` https://doi.org/10.48324/dandi.001832/0.260611.2102 Analysis code is available on GitHub https://github.com/vernonclarke/analysis_Belal2026 The analysis code is archived on Zenodo https://doi.org/10.5281/zenodo.20658500 Computational modeling figures Figure 4, Figure 5, Figure 6 and Figure S1-S4, are not included in this processed data folder. See the GitHub repository and Zenodo analysis-code archive listed below for these workflows Computational modeling code is available on GitHubhttps://github.com/vernonclarke/msNEURON_Belal2026 The computational modeling code is archived on Zenodo https://doi.org/10.5281/zenodo.20705696