Gene Expression Analysis in Clonal Evolution of Fanconi Anemia
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https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003024.v1.p1
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We examined hematopoietic progenitor cells derived from iPSCs from patients with Fanconi anemia, including bone marrow failure cells (FANCA-/- HPCs), 'healthy', complemented cells (FANCA-/- cells with a wild-type FANCA cDNA), MDS-like cells (FANCA-/- HPCs with introduced mutations in RUNX1 and other MDS-associated genes), and Fanconi AML-like cells ('FAL'; MDS-like cells expressing FLT3-ITD).]]>
Individuals with Fanconi anemia, complementation group A]]>
This study was performed at Boston Children's Hospital from 2020-2022 using specimens shared by collaborators at Cincinnati Children's Hospital Medical Center]]>
创建时间：
2022-08-12
