Effect of Phoenix dactylifera extracts on anti-inflammatory, anticoagulant, analgesic and antidepressant activities.pdf

Phoenix dactylifera L. is a medicinal plant and it is extensively used in the prevention and cure of chronic diseases. The present study investigated the effects of antidepressant, analgesic, anti-inflammatory and anticoagulant activities in rats by P. dactylifera extracts. Methanolic extracts of P. dactylifera fruit extract (PDF), P. dactylifera seed extract (PDS) and P. dactylifera fruit and seedextract mixture (PDM) for antidepressant, analgesic, anti-inflammatory and anticoagulant activities inSprague Dawley rats at 300, 200 and 100mg/kg body weight. Results indicated that TST and FSTshowed that rats struggling with efforts and immobility time were higher in PDS, while locomotory behavior and immobility time were significantly increased in PDS and PDM, respectively. All extracts showed good antidepressant activity, but PDS showed the highest value, while analgesic activity and edema reduction were demonstrated by PDF. In addition, PDM revealed significant anticoagulant activity and moderate activity in PDF. We can conclude that Phoenix dactylifera extracts prolong theclotting time and have the potential to reduce the platelet aggregations, depression and inflammation.Further studies needed to determine the active components responsible for pharmacological effects.