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Acute loss of TET function results in aggressive myeloid cancer in mice

ChEBI2015-11-26 更新2026-07-12 收录

髓性白血病机制

表观遗传与癌症模型

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-72630 数据链接链接失效反馈

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Acute loss of TET function results in aggressive myeloid cancer in mice

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创建时间：

2015-11-26

髓性白血病机制

TET蛋白功能

TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumor suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is

NIAID Data Ecosystem110

RNA sequencing for AML patients with and without extramedullary infiltration

髓性白血病机制

单细胞RNA测序

Extramedullary infiltration (EMI) is a concomitant manifestation indicating poor prognosis of acute myeloid leukemia (AML), yet the underlying mechanism remains poorly understood and therapeutic optio

NIAID Data Ecosystem50

Genomic Medicine & Hematology/Oncology (GeM-Onco). Homo sapiens

肿瘤基因组学

髓性白血病机制

Whole-Exome Sequencing of Chronic Myeloid Leukemia patients to find out genomic variants associated with disease progression and druggabilityCML-NGS-Raw1 https://1drv.ms/f/s!Ai2Oaa5jGDDxgadsrUzjykJ91b

NIAID Data Ecosystem40

BCL11A promotes myeloid leukemogenesis by abrogating the transcriptional activity of PU.1

髓性白血病机制

转录调控

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem60

Transcriptome profiling of Bmi1 silenced-K562 CML cell line. Homo sapiens

髓性白血病机制

基因表达谱分析

The Bmi1 Polycomb protein is involved in the epigenetic repressive control of self renewal and survival of cancer initiating cells. In Chronic Myeloid Leukemia (CML), bmi1 expression increases gradual

NIAID Data Ecosystem40

Acute loss of TET function results in aggressive myeloid cancer in mice

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