Bypass mechanisms of the AR pathway in castration-resistant PC346 prostate cancer cells

ChEBI2010-10-21 更新2026-07-21 收录

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Bypass mechanisms of the AR pathway in castration-resistant PC346 prostate cancer cells

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2010-10-21

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance. GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

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雄激素受体信号

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here we show that the magnitude of AR signaling output, independent of AR

NIAID Data Ecosystem70

RNA-Seq of LNCaP human prostate cancer cells with knockdown of MAP3K7 and/or CHD1

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Purpose: The goal of this study is to identify transcriptome-wide changes that occur in a human prostate cell line with knockdown of MAP3K7(TAK1) and CHD1, in the presence and absence of androgens. We

NIAID Data Ecosystem50

Androgen receptor RIP-seq of LNCaP cells treated with androgen hormone. Homo sapiens

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lincRNA转录调控

In this work we reported in a high-throughput way (RIP-seq) the RNAs associated with androgen receptor after treatment with androgen hormone. We used a large compilation of lincRNAs to describe the di

NIAID Data Ecosystem50

Genome-wide AR binding under androgen deprivation condition upon TRAF4 overexpression. Genome-wide AR binding under androgen deprivation condition upon TRAF4 overexpression

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全基因组结合位点分析

We report that TRAF4-mediated AR ubiquitination alters AR genomic binding profile under androgen deprivation condition. Overall design: Examination of AR genome-wide binding in control and TRAF4 overe

NIAID Data Ecosystem50

RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway

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The aim of this research was to confirm the regulatory effect of RUVBL1 on gene expression in castration resistant prostate cancer. In this research, there were six samples examined including samples

NIAID Data Ecosystem50

Bypass mechanisms of the AR pathway in castration-resistant PC346 prostate cancer cells

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