TransLnc

TransLnc provides both computationally predicted and experimentally supported lncRNA peptides in multiple species. Six kinds of direct and indirect experimental evidences are integrated to support the coding potential of lncRNAs and peptides, including manually curation, the occupancy of ribosomes, lncORF, IRES, m6A and mass spectrometric proofs. TransLnc currently documents approximate 583,840 peptides encoded by 33,094 lncRNAs. TransLnc also concludes 220,791 and 237,915 candidate neoantigens binding by major histocompatibility complex class I or II molecules, respectively.

TransLnc 提供多物种中经计算预测与实验验证的长链非编码RNA（long non-coding RNA, lncRNA）编码肽段数据。该数据库整合了6类直接与间接实验证据，以验证长链非编码RNA及其编码肽段的编码潜能，涵盖人工注释、核糖体结合特征、长链非编码RNA开放阅读框（lncORF）、内部核糖体进入位点（internal ribosome entry site, IRES）、N6-甲基腺嘌呤（m6A）以及质谱验证证据。截至当前，TransLnc 共收录了由33094条长链非编码RNA编码的约583840条肽段。此外，TransLnc 还分别收录了220791条与237915条可与主要组织相容性复合体（major histocompatibility complex, MHC）I类或II类分子结合的候选新抗原。

搜集汇总

背景与挑战

背景概述

TransLnc是一个全面的可翻译lncRNAs数据库，涵盖人类、小鼠和大鼠三个物种，包含583,840个计算预测的肽段和381,105个实验验证的lncRNA肽段。该数据库还提供多种分析工具，支持lncRNAs编码潜力的实验证据和临床相关性研究。