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Design and Synthesis of C6−C8 Bridged Epothilone A

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Design_and_Synthesis_of_C6_C8_Bridged_Epothilone_A/2944315
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资源简介:
A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC50 = 8.5 μM) against the A2780 human ovarian cancer cell line.
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2016-06-03
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