Adult brain cortex spatial gene regulatory network

This dataset consists of spatially constrained
eQTLs. Briefly, all common single nucleotide polymorphisms (SNPs; MAF >0.05)
present in adult brain cortex tissue were obtained from GTEx v8 and used to
interrogate prepared Hi-C libraries. This allowed for the identification of
SNP-gene pairs that are physically interacting. The identified SNP-gene pairs
were then tested for eQTL effects by integrating eQTL data from GTEx v8. eQTLs
with an adjusted p-value ≤0.05 were selected as being significant
(Benjamini-Hochberg).

本数据集由空间约束的eQTLs组成。简而言之，所有在成年大脑皮层组织中存在的常见单核苷酸多态性（SNPs；MAF >0.05）均来自GTEx v8版本，并用于探究已制备的Hi-C文库。此举有助于识别物理相互作用的SNP-基因对。随后，通过整合GTEx v8版本的eQTL数据，对识别出的SNP-基因对进行了eQTL效应的检测。调整后的p值≤0.05的eQTLs被视为具有显著性（Benjamini-Hochberg方法）。