Mosquito metabolism shapes life-history strategies of Plasmodium parasites

This project simulates mosquito population dynamics and malaria transmission as described in the research paper "Mosquito metabolism shapes Plasmodium life-history traits". The modelling framework consists of an individual-based model with an extensive description of mosquito biology. Specifically, this is the first model that includes a description of nutrient allocation inside female mosquitoes and their interactions with growing malaria parasites. Description of the data and file structure The data from our simulations is organized with variations based on different initial Tsp values and whether the model excluded (control) or included mosquito metabolism (metabolism). The directories are organized as follows: 1. Control simulations You will find three directories named "control_11", "control_12", and "control_13", where all results from the simulations excluding mosquito metabolism (control model), and with different starting conditions for Tsp, i.e., Tsp(0) = 11 - 13 days. 2. Metabolism simulations Similarly, you will find three directories named "metabolism_11", "metabolism_12", "metabolism_13", where results from simulations including the description of mosquito metabolism are stored. 3. Evolutionary simulations You will find four directories that follow a structure for both conditions (control and metabolism) and initial Tsp values (Tsp(0)) "condition_evo_TSP(0)". In every directory, you will find a subdirectory with all the simulated and analyzed data. Every simulation produces the following files: femaleParameters.csv humanParameters.csv IncubationPeriod.csv larvaParameters.csv PopulationSize.csv TransmissionProfileMosquitoes.csv Code/Software The individual-based model was implemented in the C++ programming language. All analysis were performed using R version 3.5. The code is available under: https://gitlab.mpcdf.mpg.de/vectorbiology/mosquito_metabolism/vectorbornemodel_release

本项研究模拟了蚊虫种群动态及疟疾传播过程，其描述依据于学术论文《蚊虫新陈代谢塑造疟原虫生命史特性》。该建模框架采用基于个体的模型，对蚊虫生物学进行了详尽的描述。特别是，本模型首次纳入了雌蚊内部营养分配及其与生长疟原虫的相互作用描述。数据与文件结构描述：本模拟数据根据不同的初始Tsp值及其是否排除（对照）或包含蚊虫新陈代谢（新陈代谢组）进行了组织。目录结构如下：1. 对照模拟：您将发现三个名为“control_11”、“control_12”和“control_13”的目录，其中包含排除蚊虫新陈代谢（对照模型）的模拟结果，以及Tsp的初始条件，即Tsp(0) = 11 - 13天。2. 新陈代谢模拟：类似地，您将找到三个名为“metabolism_11”、“metabolism_12”和“metabolism_13”的目录，其中存储了包含蚊虫新陈代谢描述的模拟结果。3. 进化模拟：您将发现四个目录，它们遵循对照和代谢条件以及初始Tsp值（Tsp(0)）“condition_evo_TSP(0)”的结构。在每个目录中，您将找到一个包含所有模拟和分析数据的子目录。每次模拟均生成以下文件：femaleParameters.csv、humanParameters.csv、IncubationPeriod.csv、larvaParameters.csv、PopulationSize.csv、TransmissionProfileMosquitoes.csv。代码/软件：基于个体的模型是用C++编程语言实现的。所有分析均使用R版本3.5进行。代码可在以下链接获取：https://gitlab.mpcdf.mpg.de/vectorbiology/mosquito_metabolism/vectorbornemodel_release