The gene regulation of FAM198B in lung cancer

FAM198B is identified as a novel tumor supressor gene in lung adenocarcinoma. This study aim to investigate the effects of the glycoprotein protein, FAM198B, on the biological behavior and global gene expression profiles of lung cancer cells. Expression microarray and bioinformatics analyses indicated that FAM198B mainly regulated ERK-mediated MMP1 pathway in CL1-5 cells, which results in tumor metastasus inhibition. We used microarrays to identify the global gene alterarion in lung cancer CL1-5 cells after ectopic expressing FAM198B Etopic expressing FAM198B-V5 and mock control vector in lung cancer CL1-5 cells