Additional file 2 of Saliva as a non-invasive specimen for COPD assessment

Additional file 2: Supplementary Methods. Table S2. Summary of clinical parameters distribution across Clusters I and II. Comparisons between clusters were conducted with Mann-Whitney U-test and chi-square test. Table S3. Summary table of significant logistic regression models established for both GOLD D and hospital admission, adjusted for Pack-years. Coefficients were represented in model equations. Figure S1. Salivary bacteria composition is different between patients with COPD and healthy controls. A) Bar-plot representing the differentially abundant genera between moderate patients with COPD and healthy controls inferred by LEfSe at a significance cut-off of 3. B) Bar-plot representing the differentially abundant genera between moderate patients with COPD and healthy controls inferred by LEfSe at a significance cut-off of 3. C) Bar-plot representing the differentially abundant genera between severe patients with COPD and healthy controls inferred by LEfSe at a significance cut-off of 3. A), B) and C) Differentially abundant OTUs inferred by ANCOM at 0.7 significance cut-off are underlined. Figure S2. Salivary bacteria composition is different between the two clusters. Bar-plot representing the differentially abundant genera between cluster I and cluster II inferred by LEfSe at a significance cut-off of 3. Differentially abundant OTUs inferred by ANCOM at 0.7 significance cut-off are underlined.