CD38-NAD+ Immuno-Metabolic Axis Regulates Potent Anti-Tumor T Response
收藏官方服务：
资源简介：
CD38-NAD+ Immuno-Metabolic Axis Regulates Potent Anti-Tumor T Response
应用场景：
创建时间：
2017-09-13
相关数据集
DataSheet_1_Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.zip
IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows s
NIAID Data Ecosystem30
Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.
Transcriptional profiling of transitional and follicular B cells showed that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice, characterized by an orchestrated
NIAID Data Ecosystem10
Acetyl-CoA Carboxylase-1 Inhibition Increases Regulatory T-Cell Metabolism, Mitochondrial Fusion and Graft-vs-Host Disease Treatment Efficacy [L2_cGvHD]
Regulatory T-cells (Treg) are critical for maintaining immune homeostasis, and their adoptive transfer can treat murine inflammatory disorders. In patients, Treg therapies have been variably efficacio
NIAID Data Ecosystem00
Requirement of mitochondrial transcription factor A in interleukin-17-producing gdT cells to regulate the small intestine homeostasis and metabolism. Requirement of mitochondrial transcription factor A in interleukin-17-producing gdT cells to regulate the small intestine homeostasis and metabolism
Interleukin 17 (IL-17)-producing gamma delta T (gdT17) cells are one of the major cellular sources of IL-17 under the steady state and in disease. However, gdT17 cell metabolism and its role in tissue
NIAID Data Ecosystem30
Immune response-related genes most strongly associated with survival in adult GBMa.
aCoxBoost modeling was performed on 58 immune response-related genes from the TCGA worst prognosis signature [9].bCoefficient for the standardized covariates in the Cox proportional hazards model.
Figshare2015-12-02 更新00
