Comparison of dopamine release and uptake parameters across sex, species and striatal subregions

Dopamine in the striatum strongly regulates behavioral output in a heterogenous across the various striatal subregions. Moreover, dopamine dynamics not only displays heterogeneity across brain structures but also within males and females. The purpose of this dataset was to evaluate the dopamine dynamics in male and female mice and rats across five subregions: the dorsolateral caudate, ventromedial caudate, nucleus accumbens core, nucleus accumbens lateral shell, and the nucleus accumbens medial shell. Fast scan cyclic voltammetry (FSCV) was employed to measure dopamine release and uptake following a single pulse electrical stimulation in each of these subregions within a single brain slice. The dopamine dynamics were also observed across a variety of stimulation amplitudes. The goal of this dataset was to produce systematic FSCV measurements of dopamine across the rodent striatum using FSCV which would be available as a resource for further investigation of DA terminal function., Detailed methods can be found in the manuscript., , # Comparison of dopamine release and uptake parameters across sex, species and striatal subregions

[https://doi.org/10.5061/dryad.sf7m0cgcn](https://doi.org/10.5061/dryad.sf7m0cgcn)

## Description of the data and file structure

This data set includes 12 mice (6 male, 6 female) and 12 rats (6 male, 6 female). One rostral (mouse: 1.33-1.09 AP; rat: 2.20-1.60 AP) and one caudal (mouse: 0.97-0.73 AP, rat: 1.20-0.70 AP) brain slice from each animal hemisected so that a total of 4 data points were collected per animal. All slices were run in parallel, and an additional slice was collected from each animal to serve as a control for slice health and electrode stability throughout the recording period. Data identifiers have been designated as follows: Species (Ms= mouse or Rt=rat), Sex (M=male; F=female), animal number, slice identity (r=rostral, c=caudal), slice number. Example: MsM1_r1 would be mouse, male 1, rostral slice 1. 

The study was designed to maximize the data collected, allowing...