Comparison of dopamine release and uptake parameters across sex, species and striatal subregions

Dopamine in the striatum strongly regulates behavioral output in a heterogenous across the various striatal subregions. Moreover, dopamine dynamics not only displays heterogeneity across brain structures but also within males and females. The purpose of this dataset was to evaluate the dopamine dynamics in male and female mice and rats across five subregions: the dorsolateral caudate, ventromedial caudate, nucleus accumbens core, nucleus accumbens lateral shell, and the nucleus accumbens medial shell. Fast scan cyclic voltammetry (FSCV) was employed to measure dopamine release and uptake following a single pulse electrical stimulation in each of these subregions within a single brain slice. The dopamine dynamics were also observed across a variety of stimulation amplitudes. The goal of this dataset was to produce systematic FSCV measurements of dopamine across the rodent striatum using FSCV which would be available as a resource for further investigation of DA terminal function., Detailed methods can be found in the manuscript., , # Comparison of dopamine release and uptake parameters across sex, species and striatal subregions [https://doi.org/10.5061/dryad.sf7m0cgcn](https://doi.org/10.5061/dryad.sf7m0cgcn) ## Description of the data and file structure This data set includes 12 mice (6 male, 6 female) and 12 rats (6 male, 6 female). One rostral (mouse: 1.33-1.09 AP; rat: 2.20-1.60 AP) and one caudal (mouse: 0.97-0.73 AP, rat: 1.20-0.70 AP) brain slice from each animal hemisected so that a total of 4 data points were collected per animal. All slices were run in parallel, and an additional slice was collected from each animal to serve as a control for slice health and electrode stability throughout the recording period. Data identifiers have been designated as follows: Species (Ms= mouse or Rt=rat), Sex (M=male; F=female), animal number, slice identity (r=rostral, c=caudal), slice number. Example: MsM1_r1 would be mouse, male 1, rostral slice 1. The study was designed to maximize the data collected, allowing...纹状体（striatum）内的多巴胺对行为输出具有强烈调控作用，且该调控作用在不同纹状体亚区间存在异质性。此外，多巴胺动力学不仅在不同脑结构间存在异质性，在雄性与雌性个体间亦存在差异。本数据集旨在检测雌雄小鼠与大鼠的5个纹状体亚区中的多巴胺动力学，这5个亚区分别为：背外侧尾状核、腹内侧尾状核、伏隔核核心区、伏隔核外侧壳以及伏隔核内侧壳。本研究采用快速扫描循环伏安法（Fast Scan Cyclic Voltammetry, FSCV），在单脑片的上述各亚区中，检测单脉冲电刺激诱发的多巴胺释放与摄取过程，同时记录了不同刺激强度下的多巴胺动力学变化。本数据集的核心目标是通过FSCV对啮齿类纹状体全区间的多巴胺进行系统性检测，所得数据可作为研究多巴胺能轴突终末功能的公共资源。详细实验方法可参见相关手稿。 # 不同性别、物种与纹状体亚区间多巴胺释放与摄取参数的比较 https://doi.org/10.5061/dryad.sf7m0cgcn ## 数据与文件结构说明 本数据集包含12只小鼠（6雄6雌）与12只大鼠（6雄6雌）。每只动物取单侧脑的吻侧（小鼠：前后坐标1.33-1.09 AP；大鼠：前后坐标2.20-1.60 AP）与尾侧（小鼠：前后坐标0.97-0.73 AP；大鼠：前后坐标1.20-0.70 AP）脑片各一张，因此每只动物共计采集4组数据。所有脑片同步进行实验，同时每只动物额外采集一张脑片，用于在整个记录周期内作为脑片状态与电极稳定性的对照样本。数据标识符命名规则如下：物种（Ms=小鼠，Rt=大鼠）、性别（M=雄性；F=雌性）、动物编号、脑片类型（r=吻侧，c=尾侧）、脑片编号。示例：MsM1_r1代表第1只雄性小鼠的吻侧脑片1号。 本研究旨在最大化采集的数据量，以实现……