Crystal structure of human GSK3B in complex with ARN25565

Crystal structure of human GSK3B in complex with ARN25565 Descriptor: Glycogen synthase kinase-3 beta, ~{N}4-(3-cyclobutyl-1~{H}-pyrazol-5-yl)-~{N}2-(pyridin-3-ylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine Authors: Dalle Vedove, A, Demuro, S, Di Martino, R.M.C, Balboni, B, Tripathi, S.K, Storici, P, Girotto, S, Cavalli, A. Deposit date: 2024-06-18 Release date: 2026-01-14 Last modified: 2026-07-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3 beta /FYN-alpha /DYRK1A) Inhibitors. J.Med.Chem., 69, 2026人源糖原合成酶激酶3β（GSK3B）与ARN25565复合物的晶体结构 描述：糖原合成酶激酶3β，N4-(3-环丁基-1H-吡唑-5-基)-N2-(吡啶-3-基甲基)噻吩并[3,2-d]嘧啶-2,4-二胺 作者：Dalle Vedove, A、Demuro, S、Di Martino, R.M.C、Balboni, B、Tripathi, S.K、Storici, P、Girotto, S、Cavalli, A 提交日期：2024-06-18 发布日期：2026-01-14 最后更新日期：2026-03-04 实验方法：X射线衍射（分辨率2.3 Å） 引用文献：《揭示平衡型三重靶点GSK3B/FYN/DYRK1A抑制剂的药效团特征：用于治疗阿尔茨海默病及相关tau蛋白病的含氨基吡唑骨架的理性设计与合成》，待发表