Transcriptomic of ileocecal junction of DBA/1 mice with spontaneous arthritis (SpAD)

The spontaneous arthritis (SpAD) model in the DBA/1 mouse strain resembles the Spondyloarthritis human disease, including the intestinal inflammation characterized by loss of the integrity of the epithelial barrier and increased permeability. The transcriptome characteristics in this mouse model's gut are very scarce. Transcriptome analysis was performed using DNA microarrays of ileocolic junction of DBA/1 strain mice with spontaneous arthritis (SpAD). The spontaneous arthritis (SpAD) model was generated in the DBA/1 mouse strain as described for the model. After sacrifice, the ileocolic junction was dissected, and total RNA was extracted and hybridized on Affymetrix microarrays.