Dataset from Epidemiology of Diabetes Interventions and Complications (EDIC)

Objective: The Diabetes Control and Complications Trial (DCCT) demonstrated the powerful
impact of glycemic control on the early manifestations of microvascular complications.
Contemporary prospective data on the evolution of macrovascular and late microvascular
complications of type 1 diabetes are limited. The Epidemiology of Diabetes Interventions and
Complications (EDIC) study is a multi-center, longitudinal, observational study designed to
utilize the well-characterized DCCT cohort of ~1,400 participants to determine the long-term
effects of prior separation of glycemic levels on micro- and macrovascular outcomes. The
current phase of EDIC also focuses on the interaction between and the effects of aging and
long-duration diabetes on cognitive and physical function as well as the long-term effects of
diabetes-related complications on quality-of-life and health care costs. EDIC is in its 27th
year of follow-up.

Methods: Data collection focuses on micro- and macrovascular complications. Annual or
biennial measurements (using DCCT methods, standardized protocols and central laboratories)
of vascular events, albumin excretion, GFR, ECG, ankle-brachial BP index, serum lipids and
HbA1c allows the following analyses: 1) continuation of intention-to-treat analyses to
determine long-term effects of prior separation of glycemic levels; 2) risk factors for
macrovascular outcomes; 3) correlation of progression of micro- and macrovascular outcomes.