Literature review of occurrence and transmission dynamics of SARS-CoV2 in mammal animals

A literature review has been conducted, focusing on susceptibility of wild and domestic animal species reported under field and laboratory conditions, considering different diagnostic tests (e.g., virus isolation, RNA and antibody detection), infection dynamic, pathogenesis, immunity and further transmission of the virus. Review protocol and data extraction tables are available.

The following review questions were considered:

Which mammal species have been reported positive to SARS CoV 2 in the field (either at RNA, isolated virus, antibodies), and their geographical distribution?

Which wild and domestic mammal species are susceptible to SARS CoV 2 in laboratory conditions

Dynamic of infection and pathogenesis:

What are confirmed infection routes for these species?

What is the length of the incubation period in these species

What are the clinical signs, if any, their severity, duration, etc.

Which species are able to shed the virus (even in absence of clinical signs)

Do these species develop protective immunity

Which of these species can further transmit the disease to same/other species ?

What are the genetic virus variants in each species where it is isolated?

In which animals vaccines against SARS CoV 2 have been tested, and what are the results in terms of immunogenicity, protection to challenge, or safety?

Which diagnostic tests are used in animals to detect SARS CoV

Type of test

Test performance (Se, Sp)

Sample matrix used