Meta-Analysis dataset: Methionine Sources for Weaned pigs

The datasets generated in the trials and by simulation during the current study belong to His Majesty the King in Right of Canada, as represented by the Minister of Agriculture and Agri-Food Canada. Data use is subject to obtaining permission of the representative of His Majesty the King in Right of Canada. Please contact the author for further information. Data collection (search strategy and inclusion criteria) A systematic review was conducted using the PRISMA statement (Page et al., 2021) to update the dataset previously used in a meta-analysis (Remus et al., 2015). The platforms Pubmed (126 references), ProQuest (235 references), Scopus (143 references) and Science Direct (1,663 references) were searched to identify studies reporting experimental dose-response results for the different Met sources used in pigs from weaning to finishing. The review question was proposed using the “PICo” framework, where a set of keywords was created, including elements designating population (pigs, piglets), interest (Met requirements, Met supplementation), and context (growth performance). After 293 duplicate references were removed, 1,898 studies remained. These studies were analyzed according to the following selection criteria: 1) research must have been conducted on pigs; 2) the paper must have been published between 1990 and 2021; 3) and it must present growth performance data. Based on these criteria, 1,779 papers were eliminated after the titles were assessed, while another 74 were eliminated after reading the abstract. An additional search in Google Scholar was performed. The keywords used were “pigs,” “Met,” and “growth,” and 24 adittional papers were selected according to the three previously stated criteria. At this step, the database comprised 45 references that were individually screened for full-text analysis. The inclusion criteria were as follows: 1) Studies must present treatments with different sources of free Met such as L-Met, DL-Met and/or OH-Met; 2) Free Met must have been provided at one or more inclusion levels; 3) Met must be the first limiting amino acid according to the material and methods; 4) Papers must present the nutritional composition of the experimental diets. A total of 33 studies were retained for the meta-analysis at the end of the evaluation process. Due to the small number of studies on the growing and finishing phase, only the post-weaning phase (5-25 kg body weight) was included in the analysis. Post-weaning data were present in 24 papers used in the meta-regression and meta-analysis. The ingredient composition of each diet was computed in spreadsheets and used to estimate (recalculate) the dietary composition in terms of net energy, SID AA, as well as mineral composition using the software EvaPig®. When available, the analyzed total AA composition provided by the authors was used to estimate SID values with EvaPig®. The codes used in the database are described on the Legend sheet.本研究中试验与模拟生成的数据集归属于加拿大国王（以加拿大农业与农业食品部部长为代表），数据使用需获得该代表的许可，详情请联系作者咨询。 数据收集（检索策略与纳入标准） 一项系统综述遵循PRISMA声明（Page等人，2021）开展，用于更新此前一项荟萃分析（Remus等人，2015）中使用的数据集。检索平台包括PubMed（126篇文献）、ProQuest（235篇文献）、Scopus（143篇文献）及Science Direct（1663篇文献），旨在筛选出报道猪从断奶到育肥阶段不同甲硫氨酸（Met）来源试验剂量反应结果的研究。本次综述问题采用"PICo"框架构建，构建的关键词组涵盖研究对象（猪、仔猪）、研究主题（甲硫氨酸需求、甲硫氨酸补充）及研究背景（生长性能）。移除293篇重复文献后，剩余1898篇研究。 随后按照以下筛选标准进行分析：1）研究对象为猪；2）论文发表时间介于1990年至2021年之间；3）需提供生长性能数据。经标题筛选后排除1779篇文献，阅读摘要后再排除74篇。后续在谷歌学术（Google Scholar）中进行补充检索，使用关键词"pigs"、"Met"及"growth"，并依据前述三项标准新增筛选24篇文献。至此，数据库共纳入45篇文献，对其全文进行逐一筛查。 本次纳入标准如下：1）研究需设置不同游离型甲硫氨酸来源的处理组，如L-甲硫氨酸（L-Met）、DL-甲硫氨酸（DL-Met）和/或羟基甲硫氨酸（OH-Met）；2）需设置一个或多个游离型甲硫氨酸添加水平；3）根据材料与方法部分，甲硫氨酸需为第一限制性氨基酸；4）论文需提供试验日粮的营养组成。经评估流程最终纳入33项研究用于荟萃分析。由于生长与育肥阶段的研究数量较少，本次分析仅纳入断奶后阶段（体重5~25 kg）的数据。24篇文献提供了断奶后阶段数据，用于元回归与荟萃分析。 使用电子表格计算每份日粮的原料组成，并通过EvaPig®软件估算（重新计算）日粮的净能、标准回肠可消化（SID）氨基酸及矿物元素组成。若作者提供了实测的总氨基酸组成，则通过EvaPig®软件估算其标准回肠可消化氨基酸值。 数据库所使用的代码详见Legend工作表。