Results of single-trait MR analyses after pruning for genetic instruments associated with other lipid traits.

For each exposure, genetic instruments that were associated (P < 0.001) with the other 2 listed lipid traits were removed before this MR analysis. Lipid summary statistics were from MVP, MR tests used the IVW method, and risk for all BCs was the outcome. Exposure: lipid trait used as the exposure; N_SNPs: number of genetic instruments used in MR test; CI_95_L: lower bound of 95% CI; CI_95_U: upper bound of 95% CI; P: P-value of MR test. BC, breast cancer; CI, confidence interval; HDL, high-density lipoprotein; IVW, inverse-variance weighted; LDL, low-density lipoprotein; MR, Mendelian randomization; MVP, Million Veteran Program; OR, odds ratio; TG, triglyceride.
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