Metabolomic signatures after genetic selection of litter size homogeneity in a maternal rabbit line

This study provides a plasma metabolomic characterization of genetic resilience in rabbits, estimated as the intra-dam phenotypic variance of litter size (Ve) in a 17-generation divergent selection experiment. Using an untargeted metabolomics approach we identified metabolomic signature of resilience in generation 17 using a combined classification-regression analysis. We also identified two important log ratios consistently appeared across two different generations with similar pattern of differences between the lines.