LC-MS/MS data of Extracellular Vimentin

Angiotensin-converting enzyme 2 (ACE2) has been identified as a key entry receptor for SARS-CoV-2. The involvement of other cellular components that partake in viral entry appears to be likely but is not yet fully understood. Here we describe the identification of vimentin (VIM), an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells. Using liquid chromatography–tandem mass spectrometry (LC-MS/MS), we identified VIM as a protein that binds to the SARS-CoV-2 spike (S) protein.