Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2

Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 Descriptor: 1,2-ETHANEDIOL, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, MAGNESIUM ION, ... Authors: Yang, Y, Nguyen, L.A, Smithline, Z.B, Steitz, T.A. Deposit date: 2018-02-20 Release date: 2018-08-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife, 7, 2018

HIV-1 Y188L突变型逆转录酶与非核苷类抑制剂K-5a2结合的晶体结构。组成描述符：1,2-乙二醇、4-[(4-{[4-(4-氰基-2,6-二甲基苯氧基)噻吩并[3,2-d]嘧啶-2-基]氨基}哌啶-1-基)甲基]苯-1-磺酰胺、镁离子等。作者：Yang Y、Nguyen L.A、Smithline Z.B、Steitz T.A。提交日期：2018-02-20；发布日期：2018-08-01；最后修改日期：2023-10-04。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.94埃（Å）。引用文献：《噻吩并[3,2-d]嘧啶类非核苷抑制剂强效广谱抑制HIV-1逆转录酶的结构基础》，发表于《Elife》第7卷，2018年。