circRNADb

It has been known that circular RNAs are widely expressed in human tissues and cells, and play important regulatory roles in physiological or pathological processes. A circRNA database, named as circRNADb, containing 32,914 human exonic circRNAs carefully selected from diversified sources was established. The detailed information of the circRNA, including genomic information, exon splicing, genome sequence, internal ribosome entry site (IRES), open reading frame (ORF) and references were provided in circRNADb. In addition, circRNAs were found to be able to encode proteins, which have not been reported in any species.已有研究证实，环状RNA（circular RNAs, circRNAs）广泛表达于人类组织与细胞内，并在生理或病理过程中发挥关键调控作用。本研究构建了命名为circRNADb的环状RNA数据库，该库收录了从多源数据中精心筛选得到的32914条人类外显子环状RNA。circRNADb提供了此类环状RNA的详细信息，包括基因组信息、外显子剪接特征、基因组序列、内部核糖体进入位点（internal ribosome entry site, IRES）、开放阅读框（open reading frame, ORF）以及相关参考文献。此外，研究发现环状RNA能够编码蛋白质，这一现象在既往任何物种中均未见报道。

搜集汇总

背景与挑战

背景概述

circRNADb是一个专注于人类环状RNA（circRNA）的综合数据库，包含32,914条经过注释的外显子circRNA记录。该数据库提供详细的基因组信息、IRES和ORF等数据，为大规模circRNA研究，特别是在人类领域，提供了有价值的资源。