Project title: conditional knockout of enhancer of zeste homolog 2 in unilateral ureter obstruction mice

Enhancer of zeste homolog 2 (EZH2) is a methyltransferase playing important roles in several renal diseases. It has been shown that EZH2 specific inhibitor attenuates renal interstitial fibrosis in animal models. To fully understand the mechanisms under EZH2 mediated pro-fibrotic responses, we established a unilateral ureter obstruction (UUO) model using EZH2 conditional knockout (CKO) mice. Gene expression was compared between UUO/WT and UUO/CKO group.