Effect of L-DOPA treatment on brain metabolism in the monkey Effect of L-DOPA treatment on brain metabolism in the monkey

Contributor(s): National Institute of Mental Health (U.S.) Publication: Produced: [ca. 1985] Language(s): No linguistic content Format: Still image Genre(s): Archival Materials Slides (photographs) Abstract: Sokoloff's group used the deoxyglucose method to study many brain phenomena, including the effects of various drugs on cerebral metabolism. A series of studies in the mid-1980s explored the effects of l-dopa in the brains of monkeys with parkinsonism induced by MPTP. This is one of the slides used for presentations. It's a color-coded autoradiograph of a coronal section. It shows clearly that l-dopa increases metabolism in the brains of monkeys with induced parkinsonism, though not much in normal brains. See, e.g., LG Porrino, et al., "Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by 1-methyl-phenyl-1,2,3,6-tetrohydropyridine (MPTP) in the primate," Life Sciences 40 (1987): 1657-1664. Copyright: The National Library of Medicine believes this item to be in the public domain. (More information) Extent: 1 pages NLM Unique ID: 101743402X85 (See in Profiles in Science) Profiles in Science ID: NLBBGC Permanent Link: http://resource.nlm.nih.gov/101743402X85 Archival Collection: The Louis Sokoloff Papers (Profiles in Science)