GATA-6 and NFkB Repress Caveolins Transcription in Bladder Smooth Muscle Hypertrophy. GATA-6 and NFkB Repress Caveolins Transcription in Bladder Smooth Muscle Hypertrophy

Microarray analysis of bladder RNA revealed down-regulation of CAV1, CAV2 and CAV3 gene transcription in both mice with obstruction-induced BSM hypertrophy, and in men with benign prostatic hyperplasia Knockout of NF-κB subunits or shRNA-mediated knockdown of GATA-6 in BSM increased CAV1, CAV2 and CAV3 transcription and promoter activity. Overall design: In this study, we performed a comprehensive analysis of genes regulation under conditions relevant to BSM hypertrophy and obstructive bladder disease.