X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha

X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha Descriptor: Interleukin-2,Interleukin-2 receptor subunit alpha Authors: Losey, H.C. Deposit date: 2020-02-20 Release date: 2020-04-29 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (3.4 Å) Cite: ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer, 8, 2020

ALKS 4230的X射线晶体结构，该蛋白为环化重排的人白细胞介素-2（Interleukin-2）与白细胞介素-2受体α亚基（Interleukin-2 Receptor alpha）的融合体。数据集描述：白细胞介素-2、白细胞介素-2受体α亚基；作者：Losey, H.C.；提交日期：2020-02-20；发布日期：2020-04-29；最后修改日期：2024-11-20；实验方法：X射线衍射（分辨率3.4 Å）；引用文献：ALKS 4230：一款新型工程化白细胞介素-2融合蛋白，具备优化的细胞选择性谱，可用于癌症免疫治疗。《癌症免疫治疗杂志（J Immunother Cancer）》，2020年，第8卷。