Unraveling developmental gene regulation in holometabolous insects through comparative transcriptomics and proteomics

We here provide a comprehensive paired proteome and transcriptome data set including major stages (egg, larva, pupa and adult) across the whole developmental life cycle of the silkworm Bombyx mori. Our data constitutes a rich resource enabling comparative analysis of developmental regulatory dynamics. Analyzing this paired proteome and transcriptome data we revealed similarities and differences between both levels of gene expression in B. mori. We were also able to examine protein-transcript correlations and characterize stage-specific dynamics. Integrating similar publicly available data for D. melanogaster were also compared the two holometabolous insects at the level of the developmental proteome and transcriptome.