Improved performance of NESmapper by optimization the profiles.

aThree test datasets were used for the performance evaluation. (1) The artificial NES set: 163 positive and 60 negative experimentally verified NESs; (2) the ValidNES-test set containing 92 proteins (100 NESs) from the ValidNES database of positive and negative data; (3) the Sp-test set, a negative test set containing 50 proteins from the Sp-protein dataset.bProfiles optimization was conducted using training data sets, excluding the corresponding test data.cProfiles optimization was conducted using training data sets, including the corresponding test data.N.T.: not tested.Improved performance of NESmapper by optimization the profiles.