Single cell functional genomics reveals plasticity of subcutaneous white adipose tissue (WAT) during early postnatal development. Single cell functional genomics reveals plasticity of subcutaneous white adipose tissue (WAT) during early postnatal development

We performed a large-scale single cell transcriptomic (scRNA-seq) and epigenomic (snATAC-seq) characterization of cellular subtypes (adipose stromal cells (ASC) and adipocyte nuclei) during inguinal WAT (subcutaneous; iWAT) development in mice, capturing the early postnatal period (postnatal days (PND) 06 and 18) through adulthood (PND56). Overall design: Bulk mRNA, scRNA-seq, snATAC-seq of inguinal white adipose tissue stromal cells and adipocytes during development