Usp8

ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; PARTICIPATES IN mitochondrial autophagy pathway; endocytosis pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN early endosome; glutamatergic synapse; postsynaptic density; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid

编码一种表现出半胱氨酸型去泛素化酶活性（同源）；K48连接型去泛素化酶活性（同源）；K63连接型去泛素化酶活性（同源）；参与细胞对地塞米松刺激的应答；参与细胞对神经生长因子刺激的应答；调节突触后蛋白降解过程的调控，调制突触传递；参与线粒体自噬途径；内吞作用途径；与ACTH分泌型垂体腺瘤（同源）相关；与布鲁姆综合征（同源）相关；与结直肠癌（同源）相关；存在于早期内体；存在于谷氨酸能突触；存在于突触后密度；与（+）五味子素B；2,3,7,8-四氯二苯并-对-二恶英；2,4,6-三硝基苯磺酸相互作用。