Additional file 1 of Prenatal exposure to medication and risk of childhood cancer – a systematic review and meta-analysis

Supplementary Material 1: Supplementary Figure 1. Prenatal exposure to analgesics and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available. Supplementary Figure 2. Prenatal exposure to antibiotics and the risk of childhood cancer. Abbreviations: ES, estimate; 1estimates were calculated with four-square table; * calculation of crude estimates. Supplementary Figure 3. Prenatal exposure to antiemetics and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; 1estimates were calculated with four-square table; * calculation of crude estimates. Supplementary Figure 4. Prenatal exposure to antihistamines and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; 1estimates were calculated with four-square table; * calculation of crude estimates. Supplementary Figure 5. Prenatal exposure to antihypertensives and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available. Supplementary Figure 6. Prenatal exposure to antiretroviral HIV-drugs and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; HIV, human immunodeficiency virus; * calculation of crude estimates. Supplementary Figure 7. Prenatal exposure to cold or cough remedies and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; 1estimates were calculated with four-square table; * calculation of crude estimates. Supplementary Figure 8. Prenatal exposure to diuretics and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; 1estimates were calculated with four-square table; *calculation of crude estimates. Supplementary Figure 9. Prenatal exposure to folic acid supplements and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available. Supplementary Figure 10. Prenatal exposure to hormones and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; 1estimates were calculated with four-square table; *calculation of crude estimates. Supplementary Figure 11. Prenatal exposure to iron supplements and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available. Supplementary Figure 12. Prenatal exposure to nervous system medication and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; aestimates were calculated with four-square table; *calculation of crude estimates;1 nervous system medication, 2 sedatives/tranquilizer, 3 antidepressants/anxiety medication, 4 neurally active drugs, 5 barbiturates, 6 sleeping pills/tranquillizers, 7 hypnotics and anxiolytics, 8 antidepressants, 9 sedatives, 10 tranquilizer, 11 CNS depressants, 12 sedatives, tranquilizers, or sleeping pills. Supplementary Figure 13. Prenatal exposure to vitamin and mineral supplements and the risk of childhood cancer. Abbreviations: ES, estimate; n.a., not available; 1estimates were calculated with four-square table; * calculation of crude estimates. Supplementary Figure 14. Publication bias analysis on antibiotics and the risk of ALL. Abbreviations: Conf, confidence, eff, effect, Std. err., standard error, logor, log odds ratio, MSE, mean square error, P, P-value, se, standard error, SND, standard normal deviate. Supplementary Figure 15. Publication bias analysis on vitamin and mineral supplements and the risk of ALL. Abbreviations: Conf, confidence, eff, effect, Std. err., standard error, logor, log odds ratio, MSE, mean square error, P, P-value, se, standard error, SND, standard normal deviate. Supplementary Figure 16. Publication bias analysis on vitamin and mineral supplements and the risk of CNS tumors. Abbreviations: Conf, confidence, eff, effect, Std. err., standard error, logor, log odds ratio, MSE, mean square error, P, P-value, se, standard error, SND, standard normal deviate. Supplementary Figure 17. Prenatal exposure to antibiotics in different trimesters and the risk of ALL. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; n.a., not available. Supplementary Figure 18. Prenatal exposure to analgesics and the risk of different childhood cancer sites. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CNS tumors, central nervous system tumors; n.a., not available; investigated childhood cancer site:a neuroblastoma, b early age leukemia, c infant leukemia, d childhood brain tumors, e neuroblastoma. Supplementary Figure 19. Prenatal exposure to antiemetics and the risk of different childhood cancer sites. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; ANLL, acute non-lymphoblastic leukemia; CNS tumors, central nervous system tumors; n.a., not available; investigated childhood cancer site: a AML, b ANLL. Supplementary Figure 20. Prenatal exposure to antihypertensives and the risk of ALL and solid tumors in children. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; CNS tumors, central nervous system tumors; n.a., not available; investigated childhood cancer site: aCNS tumors, b neuroblastoma, c malignant germ cell tumors. Supplementary Figure 21. Prenatal exposure to hormones and the risk of different childhood cancer sites. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; ANLL, acute non-lymphoblastic leukemia; n.a., not available; investigated childhood cancer site: a AML, b ANLL; 1 estimates were calculated with four-square table; * calculation of crude estimates. Supplementary Figure 22. Prenatal exposure to antihistamines and the risk of acute leukemia and CNS tumors in children. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; ANLL, acute non-lymphoblastic leukemia; CNS tumors, central nervous system tumors; n.a., not available; investigated childhood cancer site: a ANLL, b ALL. Supplementary Figure 23. Prenatal exposure to diuretics and the risk of CNS tumors in children. Abbreviations: ES, estimate; CNS tumors, central nervous system tumors; n.a., not available. Supplementary Figure 24. Prenatal exposure to folic acid supplements and the risk of different childhood cancer sites. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; ANLL, acute non-lymphoblastic leukemia; CNS tumors, central nervous system tumors; n.a., not available; investigated childhood cancer site:a ALL, b ANLL. Supplementary Figure 25. Prenatal exposure to nervous system medication and the risk of different childhood cancer sites. Abbreviations: ES, estimate; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; ANLL, acute non-lymphoblastic leukemia; n.a., not available; * calculation of crude estimates; investigated childhood cancer site: a AML; b ANLL; investigated type of nervous system medication: 1nervous system medication, 2 sedatives, 3 hypnotics and anxiolytics, 4CNS depressants,5 sedatives, tranquilizers, or sleeping pills, 6 antidepressants/anxiety medication, 7neurally active drugs,8 barbiturates, 9 sleeping pills/tranquillizers. Supplementary Table 1. Search Strategy. Supplementary Table 2. Quality of included studies. Supplementary Table 3. Exclusion of single studies. Supplementary Table 4. Stratification by study period. Supplementary Table 5. Stratification by study region. Supplementary Table 6. Stratification by study design. Supplementary Table 7. Stratification by exposure method. Supplementary Table 8. Stratification by controlling for confounders. Supplementary Table 9. Stratification by study quality. Supplementary Table 10. Stratification by outcome assessment.