Supplementary data

This spreadsheet holds the data used in the manuscript. The
following list explains column names: (see ReadMe.doc for more information).
subject: Each
subject has a unique letter identifier
AnonID: Anonymous
ID
Group: PD or
Control
Category:
Cognitive category. PDN = PD with normal cognition, PD-MCI = PD with Mild
Cognitive Impairment, PDD = PD with dementia, HC = healthy control.
Category_HC-MCI:
Cognitive category. However, this time 3 controls classified as MCI are
identified (C-MCI).
Convert: The
status of each individual at 1 year follow up. HC = healthy control, Stable =
Did not develop dementia, Convert = Developed dementia at 1 year.
Age_at_scan_years:
Age at assessment/scan
Age_base: Age as
study entry
time_btw_scans_years:
Time between scans measured in years.
Female: 0 = male,
1 = female
Education: years
of education
FU_1year: 1st
or 2nd scan
time: assessment
time, either baseline (study entry) or follow up (~ 1year).
time.y: time, in
years, of follow up.
GM_order.diff.and.avg:
Subject order of the 4D files associated with grey matter (swarate_GM_44.nii.gz,
swavg_GM_44.nii.gz).
Exclude.motion.T1:
T1 images excluded due to motion at Y0 or Y1.
TBSS_order.diff.and.avg:
Order of the 4D image files associated with DTI and TBSS.
ASL_order.diff:
Subject order of the 4D image file (sdiff_wecqCBF_43.nii.gz:).
ASL_order_avg.part1:
Subject order of the 4D image files (demeaned_swecqCBF_43_base_part1.nii.gz,
savg_wecqCBF_43_part1.nii.gz).
ASL_order_avg.part2:
Subject order of the 4D image files (demeaned_swecqCBF_43_base_part2.nii.gz,
savg_wecqCBF_43_part2.nii.gz).
SIENA: % brain
change between scans. Values only at baseline (first timepoint).
DTI relative motion:
average relative motion between adjacent diffusion volumes (see manuscript for
details).
mean FA/MD/L1/RD:
mean FA /MD/L1/RD values along the white matter skeleton
CBF_gm: mean grey
matter perfusion (ml/100g/min), including cortex and subcortical grey.
diff.FA.Y0-Y1 (same
for MD/CBF): raw difference between mean FA at Y0 and Y1.
per.diff.FA.Y0-Y1
(same for MD/CBF): percent difference between mean FA at Y0 and Y1.
per.diff.year.FA.Y0-Y1
(same for MD/CBF): percent difference between mean FA at Y0 and Y1, divided
by the time between Y0 and Y1.
MoCa: Montreal
cognitive assessment—global cognitive screen.
UPDRS Part 3:
Unified Parkinson’s disease rating scale, part 3, the motor score (only scores
for PD participants).
LED: Levodopa
equivalent dose.
Attention Total:
average z score for tests in the domain of attention, working memory, and
processing speed.
Executive Function
Total: average z score for tests in the domain of executive function.
Visuo-Total:
average z score for tests in the domain of visuospatial/visuoperceptual
function.
Language all Domains:
average z score for tests in the domain of Language.

Total all Domains:
global cognitive score: average z score for the domain scores (attention,
executive function, learning & memory, and visuospatial/perceptual)