ORegAnno

2017-06-02: We recently suffered a server failure and are working to bring the full ORegAnno website back online. In the meantime, you may download the complete database here: http://www.oreganno.org/dump/ ; Data are also available through UCSC Genome Browser (e.g., hg38 - Regulation - ORegAnno) https://genome.ucsc.edu/cgi-bin/hgTrackUi?hgsid=686342163_2it3aVMQVoXWn0wuCjkNOVX39wxy&c=chr1&g=oreganno The Open REGulatory ANNOtation database (ORegAnno) is an open database for the curation of known regulatory elements from scientific literature. Annotation is collected from users worldwide for various biological assays and is automatically cross-referenced against PubMED, Entrez Gene, EnsEMBL, dbSNP, the eVOC: Cell type ontology, and the Taxonomy database, where appropriate, with information regarding the original experimentation performed (evidence). ORegAnno further provides an open validation process for all regulatory annotation in the public domain. Assigned validators receive notification of new records in the database and are able to cross-reference the citation to ensure record integrity. Validators have the ability to modify any record (deprecating the old record and creating a new one) if an error is found. Further, any contributor to the database can comment on any annotation by marking errors, or adding special reports into function as they see fit. These features of ORegAnno ensure that the collection is of the highest quality and uniquely provides a dynamic view of our changing understanding of gene regulation in the various genomes.

2017年6月2日：近期我方服务器遭遇故障，正在努力恢复ORegAnno网站的全部功能。在此期间，您可通过以下链接下载完整数据库：http://www.oreganno.org/dump/；数据亦可通过UCSC基因组浏览器获取（例如，hg38 - 调控 - ORegAnno）https://genome.ucsc.edu/cgi-bin/hgTrackUi?hgsid=686342163_2it3aVMQVoXWn0wuCjkNOVX39wxy&c=chr1&g=oreganno。开放式调控注释数据库（ORegAnno）系一个开放的数据库，旨在对科学文献中已知的调控元件进行编纂。注释信息由全球用户收集，并与PubMed、Entrez Gene、EnsEMBL、dbSNP、eVOC：细胞类型本体以及分类学数据库进行自动交叉引用，在适当的情况下，提供有关原始实验所进行的信息（证据）。此外，ORegAnno还提供对公共领域内所有调控注释的开放验证流程。指定的验证者将收到数据库中新记录的通知，并能交叉引用引文以确保记录的完整性。如果发现错误，验证者有权修改任何记录（废弃旧记录并创建新记录）。进一步地，数据库的任何贡献者均可通过标记错误或添加他们认为合适的特殊报告等方式，对任何注释进行评论。ORegAnno的这些特性确保了数据集的高质量，并独特地提供了我们对基因调控在各个基因组中不断变化的理解的动态视图。