P values derived from statistical analyses of frequencies of dominant Vδ2 clonotypes between different tissues compartments (n = 5).

#p value = 0.0041(**, very significant) when frequencies of dominant Vδ2 clonotypes in blood were compared with those in spleen(Blood vs Spleen). Individual dominant Vδ2 clonotypes were defined if they comprised >20% of the clones identified in a tissue compartment or blood from a macaque. Frequencies of dominant Vδ2 clonotypes among total TCR clones in a compartment from five macaques (Figs. 1, 2, 3) were calculated and analyzed for statistical significance between different tissue compartments using two-tailed Fisher exact test. We also statistically compared percentage numbers for total distinct Vδ2-bearing clones between different tissues compartments (n = 5), and found similar trends of results suggesting that Vδ2 repertoires in blood and lung were significantly broader than those in liver and kidney(data not shown).