Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor

Protein Data Bank Japan2023-12-13 更新2026-03-21 收录

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Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor Descriptor: N-{[6-(PENTYLOXY)NAPHTHALEN-2-YL]SULFONYL}-D-GLUTAMIC ACID, SULFATE ION, UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE Authors: Humljan, J, Kotnik, M, Contreras-Martel, C, Blanot, D, Urleb, U, Dessen, A, Solmajer, T, Gobec, S. Deposit date: 2007-03-06 Release date: 2008-03-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem., 51, 2008

MurD连接酶结合含D-谷氨酸的磺酰胺抑制剂的晶体结构复合物标识：N-{[6-(戊氧基)萘-2-基]磺酰基}-D-谷氨酸、硫酸根离子、UDP-N-乙酰胞壁酰丙氨酸-D-谷氨酸连接酶作者：Humljan, J、Kotnik, M、Contreras-Martel, C、Blanot, D、Urleb, U、Dessen, A、Solmajer, T、Gobec, S. 提交日期：2007-03-06 发布日期：2008-03-25 最后修改日期：2023-12-13 实验方法：X射线衍射（分辨率2.5埃）引用文献：《新型萘-N-磺酰基-D-谷氨酸衍生物作为肽聚糖生物合成关键酶MurD的抑制剂》，《药物化学杂志（J. Med. Chem.）》，51卷，2008年

创建时间：

2007-03-06