Encapsulation of Quinine by β-Cyclodextrin: Excellent Model for Mimicking Enzyme−Substrate Interactions

An inclusion complex formed by β-cyclodextrin and quinine
has been investigated in solution and in the solid state, in
which the quinoline ring and the aliphatic ring locate in
different hydrophobic cavities, respectively. The study on
the inclusion geometry and weak interactions shows that the
difference in conformation for this complex is a result of
three main packing arrangement considerations, which can
provide an ideal model mimicking enzyme−substrate interactions.