Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) table for Skin, v1.6

Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) tables (https://humanatlas.io/asctb-tables) aim to capture<br>anatomical human body parts, the typology of cells, and biomarkers used to identify cell types. The tables are<br>authored and reviewed by an international team of experts. The Skin ASCT+B table represents terms related to the adult<br>human skin. These include both macroscopic and microscopic anatomical structures, major cell types, and protein<br>biomarkers specific for each cell type listed. This table was generated based on published histopathologic<br>nomenclature, as well as published literature on cell-type specific biomarkers. Most of the markers listed are<br>observed in more than one study or orthogonally validated. Note that these are predicted markers and a single marker<br>to annotate a cell type is not likely sufficient or specific. Where more refined cell types are not available in the<br>ontologies, the closest general term is used. For example, there are likely multiple types of skin stromal cells;<br>however, further characterization is needed to distinguish between these cell types. Where cells of similar type occur<br>in different locations, the closest and highest level of resolution available is used. For example, keratinocytes<br>occur in multiple different contexts within the skin, including the epidermis and hair follicles.<br> <br>**Bibliography:** <br><br>* Börner, Katy, Sarah A. Teichmann, Ellen M. Quardokus, James C. Gee, Kristen Browne, David Osumi-Sutherland, Bruce W. Herr II, et al. 2021. “Anatomical Structures, Cell Types and Biomarkers of the Human Reference Atlas.” *Nature Cell Biology* 23 (11): 1117–28. https://doi.org/10.1038/s41556-021-00788-6.