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Directed evolution of engineered virus-like particles with improved production and transduction efficiencies

NIAID Data Ecosystem2026-05-01 收录

病毒样颗粒

基因编辑递送

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1034592 数据链接链接失效反馈

官方服务：

资源简介：

These data were generated to evaluate gene editing using engineered virus-like particles.

应用场景：

创建时间：

2023-11-01

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VLP stoichiometry dataset

病毒样颗粒

疫苗开发

该数据集是由英国谢菲尔德大学的研究团队从RCSB蛋白质数据银行（PDB）中编译而成，包含200个蛋白质序列，旨在用于病毒样颗粒（VLP）的 stoichiometry 分类研究。数据集中的蛋白质序列经过精心筛选，确保了数据的质量和平衡性，适用于机器学习模型训练和评估。数据集的创建是为了解决疫苗开发中的 stoichiometry 问题，从而加速疫苗的设计和开发。

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Non-replicative phage particles deliverig CRISPR-Cas9 to target major blaCTX-M variants

基因编辑递送

抗微生物耐药性干预

blaCTX-M gene from this bacterial isolate was selected as a target for CRISPR-Cas9 system delivered by phage particles

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Recovery of VLP obtained after buffer variations and with the use of stabilizers during storage.

病毒样颗粒

蛋白生产优化

aVarious excipients were evaluated at different concentrations during VLP in storage at 4°C for a time period of 24 weeks after purification. The initial concentration of VLP in all samples was 500 µg

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VLP VP40 mass content determined by MRM analysis of p12

病毒样颗粒

蛋白质靶向

(XLSX)

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DNA-Free Recombinant SV40 Capsids Protect Mice from Acute Renal Failure by Inducing Stress Response, Survival Pathway and Apoptotic Arrest

急性肾损伤

病毒样颗粒

Viruses induce signaling and host defense during infection. Employing these natural trigger mechanisms to combat organ or tissue failure is hampered by harmful effects of most viruses. Here we demonst

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