Voltage-dependence of activation and inactivation of <i>Aedes aegypti</i> sodium channels and sensitivity of mutant channels to pyrethroids.

Data were fitted with the Boltzmann equation to determine V1/2, the voltage of half-maximal conductance or inactivation, and k, the slope factor. Values represent the mean ± standard errors. Voltage dependences were compared statistically between wild-type and mutant channels using one-way ANOVA followed by Dunnett's multiple comparison test. *P<0.05. Ratios were calculated by EC25 (mutant)/EC25 (wild-type). an, number of biological replications for each insecticide concentration tested. Voltage-dependence of activation and inactivation of Aedes aegypti sodium channels and sensitivity of mutant channels to pyrethroids.