ATR signaling

This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3875 CPTAC Assay Portal]

本通路模仿了文献《ATR 信号传导：不仅仅是交汇于岔路口》中的图1（参见参考文献）。该通路详述了在单链DNA出现缺口时启动的ATR信号传导过程。它详细描述了多种独立检查点蛋白的利用，这些蛋白进而引发TOPBP1依赖性的磷酸化和激酶活化，作用于大量底物，包括CHK1，从而启动对DNA损伤和复制压力的细胞反应的调控。该通路上的蛋白均有针对性的检测方法，可通过[CPTAC检测门户](https://assays.cancer.gov/available_assays?wp_id=WP3875)获取。