Single-cell Whole-Exome Sequencing of mouse thymic T cells
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https://www.ncbi.nlm.nih.gov/sra/SRP224056
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We sequenced 28 Mlh1-/- and 28 Mlh1+/+ mouse T cells together with bulk DNA samples from thymic T cells to study the mutational landscape shaped by replication errors and DNA mismatch repair (MMR). Mlh1 is an integral part of the MMR machinery, and Mlh1-/- mice are defective of MMR.
创建时间:
2020-08-18



